Niosomes from Preparation to Application in Drug Delivery

Abstract

Introduction: In recent years, the treatment strategy for infectious and autoimmune diseases has significantly changed. Up to now, cancer treatment has been conducted on the basis of clinical and pathological methods. The most common cancer treatments is limited to chemotherapy, radiation therapy and surgery. However, cancer treatment is still not optimal. Common challenges for treatment of certain disease, e.g. cancer, are: systematic and non-specific distribution of drug agents, intolerable toxicity, insufficient drug concentration at the site of treatment and drug resistance. In recent years, the development and application of nanotechnology has been considered revolutionary in the field of cancer treatment. This technology offers a unique way to early detection and treatment of cancer. Designing and developing o new drug delivery systems not only increases the drug activity in the target tissue, but also reduces the drug toxicity and leaves it in a controlled manner. Newcomer vesicles consist of non-ionic surfactants that are biodegradable, non-toxic, stable, and inexpensive and can be used for targeted drug delivery. The niosomal vesicles are composed of nonionic surfactants that are biodegradable, non-toxic, stable and lower cost; and it can be used for targeted drug delivery. The major advantages of niosomes can be mentioned: the greater chemical stability, high purity, the availability of various types of non-ionic surfactants, proper storage of drug and cheapness.