A Comprehensive Review of the Application of Metal-Organic Frameworks-Based Nanomaterials for Diabetic Wound Healing

Mohammad Ali  Ghasemzadeh; Sima  Banihashemian; Elham  Asghari; Mahsa  Javaherian

doi:10.18502/ssu.v34i1.21521

Mohammad Ali Ghasemzadeh Department of Chemistry, Qom Branch, Islamic Azad University, Qom, Iran.
Sima Banihashemian Department of Chemistry, Qom Branch, Islamic Azad University, Qom, Iran.
Elham Asghari Department of Chemistry, Qom Branch, Islamic Azad University, Qom, Iran.
Mahsa Javaherian Department of Chemistry, Qom Branch, Islamic Azad University, Qom, Iran.

DOI: https://doi.org/10.18502/ssu.v34i1.21521

Keywords: Metal-Organic Frameworks; Diabetic Wound healing; Injury; Insulin.

Abstract

Introduction: Wounds are common and inevitable occurrences caused by tissue damage. In diabetic patients, however, such injuries may lead to severe health problems. In individuals with type 2 diabetes, insufficient insulin production prevents the maintenance of normal blood glucose levels. Consequently, glucose in the bloodstream is not adequately absorbed, leading to increased blood sugar levels. Over time, this elevated glucose can damage various organs and result in scarring. Diabetic wounds significantly contribute to the mortality of diabetic patients; therefore, measures should be taken to prevent and heal these ulcers. One method for healing diabetic wounds is the use of metal-organic frameworks (MOFs). MOFs are a group of porous materials consisting of metal ions bonded to organic components. Their unique properties make them promising candidates for diabetic wound healing through mechanisms such as oxygen delivery, controlled drug release, antibacterial properties, and scaffolds for tissue regeneration. Addressing these critical challenges, MOFs offer a novel strategy to enhance the healing of diabetic wounds. Continues research on their design, performance, and biocompatibility is essential to unlock their full potential in clinical applications and ultimately improve patient outcomes. This review article discussed the significance and methods of diabetic wound healing using metal-organic frameworks.

Conclusion: Meta-organic frameworks (MOFs) show considerable potential as innovative materials for overcoming the challenges associated with diabetic ulcers.