Stem cell-based therapeutic approaches for heart failure

Vahideh  Zeighamian; Mahdieh jafari  Nodoushan; Marzieh  Lotfi

doi:10.18502/ssu.v33i6.19465

Vahideh Zeighamian Department of Molecular Medicine, School of Advanced Technologies in Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mahdieh jafari Nodoushan Department of Molecular Medicine, School of Advanced Technologies in Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Marzieh Lotfi Department of Molecular Medicine, School of Advanced Technologies in Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

DOI: https://doi.org/10.18502/ssu.v33i6.19465

Keywords: heart failure; Regenerative medicine, stem cells, cell therapy.

Abstract

Introduction: Heart failure is a prevalent cardiovascular condition and a leading cause of mortality globally, increasingly impacting health care systems. Despite the increasing prevalence of this disease, existing drug and non-drug treatments primarily concentrate on managing symptoms and cannot repair the underlying damage. Consequently, in the light of the elevated mortality rate, it is essential to discover innovative treatment approaches that can target the underlying causes and restore the heart’s normal function. In the meantime, treatments based on stem cells have emerged as promising candidates in the treatment of heart failure due to their ability to self-renew and differentiate into multiple cell lineages and tissues, immunomodulatory and antifibrotic effects. This study investigated the types of cells used, the potential of the operation, and the upcoming challenges that affected the therapeutic results of stem cells as well as ethical and safety considerations.

Conclusion: The use of stem cells can be effective in treating heart diseases.