Platelet Therapy and Ovarian Rejuvenation in Women with Premature Ovarian Failure

Marzieh Lotfi; Leila Azod; Malihe Lotfi; Fatemeh Tohidi; Seyed Hossein  Shahcheraghi

doi:10.18502/ssu.v31i7.13691

Marzieh Lotfi Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Leila Azod Cell and Molecular Biology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Malihe Lotfi Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Fatemeh Tohidi Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Seyed Hossein Shahcheraghi Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

DOI: https://doi.org/10.18502/ssu.v31i7.13691

Keywords: Premature Ovarian Failure، Platelet-rich plasma، Ovarian rejuvenation.

Abstract

Introduction: Premature Ovarian Failure (POF) is a disease that occurs before the age of 40 due to dysfunction of the ovaries. In these women، the production and secretion of estrogen hormone is not done properly. Such a situation causes irregular or interrupted periods، disturbances in the ovulation process and occurrence of menopausal symptoms. Premature ovarian failure makes it difficult for women to get pregnant، so more research in this field is necessary.

Conclusion: The results showed that one of the recommended ways to repair and regenerate the failing ovarian tissue was the use of platelet-rich plasma (PRP). The positive effects of PRP were dependent on the high concentration of growth factors in the alpha granules of platelets. The results of this review article showed that the use of platelet-rich plasma in restoring ovarian function could be considered as a treatment method in these patients.