Prothrombin Gene G20210A Variant in Angiographically Documented Patients with Coronary Artery Stenosis

Leyla Pourgholi; Hamidreza Goodarzynejad; Shayan Ziaee; Elmira Zare; Arash Jalali; Mohammadali Boroumand

doi:10.18502/jthc.v14i4.1988

Leyla Pourgholi
Hamidreza Goodarzynejad
Shayan Ziaee
Elmira Zare
Arash Jalali
Mohammadali Boroumand

DOI: https://doi.org/10.18502/jthc.v14i4.1988

Keywords: Coronary artery disease; Prothrombin; Coronary angiography; Single-nucleotide polymorphism

Abstract

Background: Studies on the association between the prothrombin G20210A variant and coronary artery disease (CAD) risk are inconclusive. This study aimed to investigate the possible association between the G20210A variant in the prothrombin gene and documented CAD and its severity.

Methods: This study enrolled 1460 patients who were consecutively admitted for elective coronary angiography. Via the standard angiographic techniques, coronary angiographies were done and the presence and severity of CAD were determined through the clinical vessel score and the Gensini score. Prothrombin G20210A genotypes were identified using PCR-RFLP.

Results: This cross-sectional study was performed on 953 men and 507 women at a mean age of 58.21±10.33 years. The median and the interquartile range for the Gensini score were not statistically significantly different between the wild (GG) and mutant (AA+GA) genotypes (P=0.440). The association between the G20210A polymorphism and the severity of CAD with respect to the vessel score also showed no significant linear trend of higher numbers of diseased vessels (P= 0.765 for the Mantel–Haenszel test of linear trend) in the AA+GA genotype as compared with the GG genotype.

Conclusion: Our data failed to confirm the hypothesis that the G20210A variant mutation may be a significant determinant of CAD risk or its severity.

J Teh Univ Heart Ctr 2019;14(4):150-155

This paper should be cited as: Pourgholi L, Goodarzynejad H, Ziaee S, Zare E, Jalali A, Boroumand M. Prothrombin Gene G20210A Variant in Angiographically Documented Patients with Coronary Artery Stenosis. J Teh Univ Heart Ctr 2019;14(4):150-155.