Cost-Effectiveness Analysis of Luliconazole vs. Oxiconazole in Tinea Treatment in a Tertiary Care Hospital

Ankita S; Chincholkar A; Pentewar G

doi:10.18502/jppm.v11i1.20274

Ankita S IMER Medical college, Talegaon Dabhade, Pune, Maharashtra, India.
Chincholkar A Pharmacology Department, MIMER Medical college, Talegaon Dabhade, Pune, Maharashtra, India.
Pentewar G Pharmacology Department, MIMER Medical college, Talegaon Dabhade, Pune, Maharashtra, India.

DOI: https://doi.org/10.18502/jppm.v11i1.20274

Keywords: Varicose veins, Venous leg ulcers, Great saphenous vein, saphenopopliteal junction, Phlebotonics, Intervention treatment

Abstract

Background: To compare the efficacy and cost-effectiveness of luliconazole 1% cream and oxiconazole 1% cream in patients of tinea corporis and cruris receiving oral itraconazole.

Methods: This was an observational study conducted between November 2022 to October 2023. In the present study, 106 patients were matched for age, sex, and severity of the disease. They received one of the three treatment groups; topical luliconazole and oral itraconazole were in Group (A), topical oxiconazole and oral itraconazole were in Group (B) while those who received only oral itraconazole were in Group (C). Study groups also received levocetirizine 5 mg orally once daily. At the end of 2nd and 4th week change in clinical parameters was noted and pharmacoeconomic ratio was calculated at the end of 4th week.

Results: The change in mean composite scores of the three study groups were compared at the end of 2nd week (group A:50.7%;group;B:48.1%;group C: 46%) and 4th week (group A:89.4%;group B:85.1%;group C:88.4%) and were not statistically significant. (p>0.05) The pharmacoeconomic ratio was least for Group C patients irrespective of severity as compared to Group A and Group B.(p<0.05).

Conclusion: The results of the present study suggests that topical luliconazole and oxiconazole are equally efficacious in patients of tinea corporis and cruris receiving oral itraconazole. Patients who received only oral itraconazole the treatment was more cost effective.