Quality Assesment and Comparative Analysis of the Ten Brands of Nimesulide Tablet in Kathmandu

Abstract

Background: Nimesulide, a widely used non-steroidal anti-inflammatory drug(NSAID), is prescribed for pain relief, osteoarthritis, and dysmenorrhea.Variations in manufacturing processes can result in quality differences acrossbrands, potentially affecting efficacy and safety. This study aims to assess thepharmacopeial quality control parameters and price variation of ten brands ofNimesulide tablets available in the Nepalese market.

Methods: Ten different brands of Nimesulide 100 mg tablets (five Nepaleseand five Indian) were randomly selected. Quality control tests, includingweight variation, hardness, friability, disintegration, dissolution, and drugcontent assay, were performed following British Pharmacopoeia standards.Price variation was also assessed.

Results: All brands met the pharmacopeial standards for weight variation,hardness, friability, disintegration, dissolution, and drug content. Minorvariations were observed in disintegration time and dissolution rates. Indianbrands were relatively more expensive than Nepalese brands.

Conclusion: meropenem and cephalosporins/siderophore cephalosporinshave similar effectiveness as therapy for gram-negative infections in HAP .