Effectiveness of Cephalosporins /Siderophore Cephalosporins Versus Meropenem as Therapy in Patients with Hospital Acquired Pneumonia

Abstract

Background: Hospital Acquired Pneumonia (HAP) or nosocomial pneumoniais an infection caused mainly by gram-negative bacteria. Carbapenems andcephalosporins/cephalosporin siderophores are effective for infectionscaused by gram-negative bacteria. Objective: To compare the effectiveness ofantibiotics from the Carbapenem group (meropenem) compared to thecephalosporin/cephalosporin siderophore group in HAP infections caused bygram-negative bacteria.

Methods: Sources of article searches used Cochrane and PubMed, whichwere then selected by the PICO method with a population of adult HAPpatients, with comparator cephalosporins/cephalosporin siderophores thathave clinical improvement outcomes with parameters of microbiologicalresponse and death, the flow chart PRISMA described it.

Results: A total of 7 articles comprehensively discussed the effectiveness ofcephalosporins/siderophore cephalosporins and meropenem againstKlebsiella pneumonia, Pseudomonas aeruginosa, and Escherichia coli. Theclinical recovery of patients after administering these two antibiotics showedhigh therapeutic effectiveness and could reduce mortality. Ceftazidime-avibactam, ceftolozane-tazobactam, and cefiderocol are new antibiotics thatare effective for HAP. Meropenem at high doses can offset the efficacy of thethree antibiotic combinations and minimize antibiotic resistance.\

Conclusion: meropenem and cephalosporins/siderophore cephalosporinshave similar effectiveness as therapy for gram-negative infections in HAP .