Association of High Levels of Testosterone and Ferritin with Overweight in Women with PCOS

Z Barartabar; H Danesh; S Mazloomi; N Alizadeh; SH Pilehvari

doi:10.18502/jabs.v11i2.8781

Z Barartabar Students Research Committee, Hamadan University of Medical Sciences, Hamedan, Iran.
H Danesh Students Research Committee, Hamadan University of Medical Sciences, Hamedan, Iran.
S Mazloomi Students Research Committee, Hamadan University of Medical Sciences, Hamedan, Iran.
N Alizadeh Department of Obstetrics and Gynaecology, Shariati Hospital, Alborz University of Medical Sciences, Alborz, Iran
SH Pilehvari Department of Obstetrics and Gynaecology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

DOI: https://doi.org/10.18502/jabs.v11i2.8781

Keywords: Testosterone, Ferritin, PCOS, Insulin, Insulin resistance.

Abstract

Background & Objective: The present study was conducted to determine testosterone and ferritin levels in women with polycystic ovary syndrome (PCOS) and investigate its relationship with body mass index (BMI)

Materials & Methods: In this case-control study, 104 PCOS cases and 99 controls were included. The concentration of testosterone, ferritin, lipid profile, insulin, glucose, and androgen was measured in fasting blood samples.

Results: Testosterone level was equal to 1.08 ± 0.50 and 0.85 ± 0.42 in the case and control groups, respectively (P< 0.001). Values of ferritin (123.45 ± 18.21ng/dl vs. 92.14 ± 17.74 ng/dl in control group, p< 0.001), insulin (11.41 ± 3.84 µU/ml vs. 7.02 ± 3.29 µU/ml in control group, p< 0.001), and insulin resistance (11.41 ± 3.84 vs.7.02 ± 3.29 in control group, p_<0.001) were also measured. There was a significant relationship between serum concentration of testosterone and ferritin with BMI) p<0.001). The role of ferritin to predict PCOS was significant (ß:-1.1, P< 0.001).

Conclusion: According to the findings of the present study, the levels of testosterone and ferritin were increased in patients with PCOS. Although elevated testosterone levels are effective in PCOS, ferritin concentration is an important factor in predicting and exacerbating the disease.