In Vitro Study of Hyaluronic Acid Based Scaffolds and Its Effect on Cartilage Regeneration

Ali Rajabi; Majid Pourentezari; Hengameh Dortaj; Abbas Shahedi; Maryam Yadegari; Sepideh  Izadi; Fatemeh Zakizadeh; Zeinolabedin  Sharifian Dastjerdi

doi:10.18502/ijml.v9i1.9081

Ali Rajabi Yazd Neuroendocrine Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Majid Pourentezari Yazd Neuroendocrine Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Hengameh Dortaj Yazd Neuroendocrine Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abbas Shahedi Yazd Neuroendocrine Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Maryam Yadegari Yazd Neuroendocrine Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Sepideh Izadi Yazd Neuroendocrine Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Fatemeh Zakizadeh Yazd Neuroendocrine Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Zeinolabedin Sharifian Dastjerdi Yazd Neuroendocrine Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

DOI: https://doi.org/10.18502/ijml.v9i1.9081

Keywords: Cartilage regeneration Chondrogenesis Hyaluronic acid In vitro Scaffold

Abstract

Recently, it has been proven that cartilage healing is difficult. The most commonly used treatments are autogenously cartilage grafting and allogeneic bone grafting, but grafts cannot fully meet treatment goals because of source, price, safety, and other concerns. Thus, a combination of biological materials and tissue engineering technology has become a recent trend in studies. Among the studies performed on tissue engineering cartilage materials are hydrogels that exhibit biological activity, post-decomposition adsorption, flexibility, and easy preparation. Cell-containing hydrogels are often used in cartilage tissue engineering because of their biocompatibility, ease of use, and ability to adapt to different defects. Hydrogels are used to mimic extracellular matrices. Although multiple materials can configure and form hydrogels, hyaluronic acid and its derivatives are distinguished. Hyaluronic acid (HA) is an extracellular molecule with several physical and biological functions found in many tissues, including cartilage. HA is formed in several biomaterial systems and scaffolding. HA hydrogels have many interests, including increased adhesion, cell proliferation, and wound healing. In addition, they represent adequate biological acting for stimulating a microenvironment for the survival of cells. However, their disadvantages include a slow degradation rate and low mechanical properties. Here, HA-based hydrogels and their applications in cartilage tissue engineering are briefly reviewed.