Comparison of Blood Biochemical Markers and Anthropometric Parameters in Different  Fatty Liver Grades

Narges   Jani; Manizheh   Azari; Sina  Jafari Ghalekohneh; Mahdie   Hemati; Javad  Mohiti-Ardekani; Azadeh  Nadjarzadeh; Yousof   Naghiaee

doi:10.18502/ijml.v8i3.7326

Narges Jani Departmet of Nutrition, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Manizheh Azari Departmet of Biochemistry and Molecular Biology, School of Medicine, Shahid Sadoughi University of Medical Science, Yazd, Iran
Sina Jafari Ghalekohneh School of Mechanical Engineering, University of Tehran, Tehran, Iran
Mahdie Hemati Departmet of Biochemistry and Molecular Biology, School of Medicine, Shahid Sadoughi University of Medical Science, Yazd, Iran
Javad Mohiti-Ardekani Departmet of Biochemistry and Molecular Biology, School of Medicine, Shahid Sadoughi University of Medical Science, Yazd, Iran
Azadeh Nadjarzadeh Departmet of Nutrition, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Yousof Naghiaee Departmet of Biochemistry and Molecular Biology, School of Medicine, Shahid Sadoughi University of Medical Science, Yazd, Iran

DOI: https://doi.org/10.18502/ijml.v8i3.7326

Keywords: Anthropometric parameters Biochemical markers Body mass index Fatty liver disease Obesity

Abstract

Background and Aims: Obesity and hyperlipidemia, diabetes, and malnutrition are among the causes of fatty liver disease. This study compares blood biochemical markers and anthropometric parameters in different grades of fatty liver.

Materials and Methods: In this descriptive cross-sectional study, 73 fatty liver patients were studied. The degree of fatty liver disease was divided into three grades on ultrasonography. Anthropometric parameters BMI, waist circumstance, height, weight in the fasting state were evaluated according to the standard protocols. The blood samples were taken and biochemical variables fasting blood sugar, serum glutamic-oxaloacetic transaminase (SGOT), Serum glutamic-pyruvic transaminase (SGPT), calcium, phosphorus, low density lipoprotein (LDL), cholesterol, triglyceride, and others were examined with photometric and HPLC methods.

Results: Statistical analysis was significant between grades 1 and 3 of fatty liver (p = 0.006) and body mass index between grades 1 and 3 of fatty liver (p = 0.003). Comparing SGOT between different grades did not show any significant differences. However, comparing Bili Total indicated a significant difference between grades 1 and 2 and 1 and 3. Moreover, statistical analysis of qualitative variables, such as gender, hypertension, smoking, drug, alcohol, heart disease, stomach disease, and kidney disease, was not statistically significant between the three fatty liver groups. Median ± IQR had a significant difference for SGOT and Bili Total (p < 0.05).

Conclusion: This study showed the significance of BMI, waist circumstance, and bilirubin factors in different grades of fatty liver. Monitoring BMI, waist circumstance, and bilirubin factors will be useful for susceptible people to non-alcoholic fatty liver disease.