RAGE p.82G>S Polymorphism Is Not Associated with the Risk of Multiple Sclerosis in Iranian Population

Abstract

Background and Aims: Multiple sclerosis (MS) is known as a partially inheritable inflammatory autoimmune disease which involves the nervous system. Different studies suggest that immune dysregulation has an important role in the pathogenesis of MS, but its exact pathomechanism has not yet been explicated. The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface molecules. In MS patients, the expression of membrane-bound RAGE on peripheral blood mononuclear cells, as well as the serum levels of the RAGE ligands are upregulated.

Materials and Methods: In this case-control study, we evaluated the association between MS incidence and RAGE p.82G>S polymorphism (rs2070600) compared with healthy controls in an Iranian population. A total of 158 patients and 156 healthy blood donors were enrolled. This polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism.

Results: Allele frequencies (p=0.319) and genotype distribution (p=0.315) of the RAGE p.82G>S gene polymorphism in MS patients and controls were not significantly different.

Conclusions: The present study indicated no relationship between RAGE p.82G>S polymorphism and the risk of MS in Iranian population.