Aptamer-Based Lateral Flow Immunoassay for Detection of D-Dimer in the Blood

Elham   Owlia; Fatemeh  Pourrajab

doi:10.18502/ijml.v11i3.19137

Elham Owlia Department of Clinical Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Fatemeh Pourrajab Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

DOI: https://doi.org/10.18502/ijml.v11i3.19137

Keywords: Aptamer, Aptasensor, D-dimer, Lateral flow, Rapid test, Venous thromboembolism

Abstract

D-dimer is an essential biomarker for thrombotic disorders. Recent studies have developed aptamer-based lateral flow immunoassays (LFIAs) to detect D-dimer rapidly. This advanced platform merges the specificity of aptamers with lateral flow technology, enabling convenient point-of-care testing. Through optimization, assays have demonstrated high sensitivity and selectivity for D-dimer detection in clinical samples, making the platform a reliable marker for thrombosis. The platform offers a practical point-of-care diagnostic solution for thrombosis, with advantages such as rapid turnaround times, ease of use, and cost-effectiveness. Herein, this literature survey tries to discuss and underscore the effectiveness of aptamer-based LFIA as an innovative method for a rapid detection of D-dimer.