HbA1c in Polycystic Ovary Syndrome as the Cardiac Risk Assessment

Arati Adhe Rojekar; Mohit Vijay Rojekar; Swati B. Ghanghurde; Poonam Lalla

doi:10.18502/ijdo.v14i1.8732

Arati Adhe Rojekar Junior Consultant, Department of IVF, PD Hinduja National Hospital and Research Centre, Mumbai, India.
Mohit Vijay Rojekar Associate Professor, Department of Biochemistry, Rajiv Gandhi Medical College, Kalwa, Thane, India.
Swati B. Ghanghurde Department of Pathology, Rajiv Gandhi Medical College, Kalwa, Thane, India
Poonam Lalla Family Physician, Chembur, Mumbai, India.

DOI: https://doi.org/10.18502/ijdo.v14i1.8732

Keywords: HbA1c, Polycystic ovary syndrome, hs-CRP, Cardiovascular disorder

Abstract

Objective: Polycystic ovary syndrome (PCOS) is an endocrine disorder associated with hyperandrogenism marked with hirsutism and ovarian dysfunction. These conditions may lead to the risk of insulin resistance (IR), type 2 diabetes, obesity, and cardiovascular disease. These conditions are related to PCOS complications hence our aim was to study and investigate the relationship between high-sensitivity C - reactive protein (hs-CPR) level and glycosylated hemoglobin (HbA1c) level in PCOS patients.

Materials and Methods: Female patients visiting the obstetrics and gynecology outpatient department (OPD), aged between 19 and 45 years with a body mass index (BMI) of 25 to 29 kg/m². The individuals fulfilling the National Institute of Health (NIH) criteria for PCOS; including amenorrhea or oligomenorrhea and had been clinically diagnosed with hyperandrogenism were served as subjects.

Results: Two hundred and ten individuals with HbA1c of 5.4% have a higher risk of cardiovascular disorders. The study showed the association between increased cardiac risk as measured by hs-CRP and patients with normal HbA1c values with a sensitivity of 77.2% and specificity of 75.99%. The HbA1c cutoff value can be used in the PCOS patients to assess the cardiac risk due to association of HbA1c cut off value with false positivity rate of 15.24%.

Conclusion: In PCOS patients with chronic low-grade inflammation, IR, and the degree of inflammation associated with HbA1c value was observed.