Non-Invasive Determination of Blood Glucose Levels by Optical Waveguide

Mohsen Askarbioki; Mojtaba Mortazavi; Abdolhamid Amooee; Saeid Kargar; Mohammad  Afkhami-Ardekani; Seyed Pezhman Shirmardi; Reihane Ranjbar Jamalabadi

doi:10.18502/ijdo.v13i4.8001

Mohsen Askarbioki Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran.
Mojtaba Mortazavi Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran.
Abdolhamid Amooee Department of General Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Saeid Kargar Department of General Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammad Afkhami-Ardekani Diabetes Research Center, Shahid Sadoughi University of Medical Sciences Yazd, Iran.
Seyed Pezhman Shirmardi Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran.
Reihane Ranjbar Jamalabadi Depatment of Pediatrics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

DOI: https://doi.org/10.18502/ijdo.v13i4.8001

Keywords: Non-invasive measurement, Hollow beam, Detection sensitivity, Divergence angle, Probe rod

Abstract

Objective: Today, there are various non-invasive techniques available for the determination of blood glucose levels. In this study, the level of blood glucose was determined by developing a new device using near-infrared (NIR) wavelength, glass optical waveguide, and the phenomenon of evanescent waves.

Materials and Methods: The body's interstitial fluid has made possible the development of new technology to measure the blood glucose. As a result of contacting the fingertip with the body of the borehole rod, where electromagnetic waves are reflected inside, evanescent waves penetrate from the borehole into the skin and are absorbed by the interstitial fluid. The electromagnetic wave rate absorption at the end of the borehole rod is investigated using a detection photodetector, and its relationship to the people's actual blood glucose level.

Following precise optimization and design of the glucose monitoring device, a statistical population of 100 participants with a maximum blood glucose concentration of 200 mg/dL was chosen. Before measurements, participants put their index finger for 30 seconds on the device.

Results: According to this experimental study, the values measured by the innovative device with Clark grid analysis were clinically acceptable in scales A and B. The Adjusted Coefficient of Determination of the data was estimated to be 0.9064.

Conclusion: For future investigations, researchers are recommended to work with a larger statistical population and use error reduction trends to improve the accuracy and expand the range of measurements.