The Effect of Resistance Training on G6Pase Gene Expression in Liver Hepatocytes, Glucose and Insulin Resistance Levels in Type 2 Diabetic Rats

Ahmad  Shokrolahi Ardakani; Hossein Abednatanzi; Mandana Gholami; Nader Shakeri

doi:10.18502/ijdo.v12i1.3634

Ahmad Shokrolahi Ardakani
Hossein Abednatanzi
Mandana Gholami
Nader Shakeri

DOI: https://doi.org/10.18502/ijdo.v12i1.3634

Keywords: Resistance training, Type 2 diabetes, Gluconeogenesis, G6Pase gene expression

Abstract

Objective: The aim of this study was to determine the effect of 12 weeks resistance training on G6Pase expression in liver cells, as well as glucose and insulin levels in type 2 diabetic rats.

Materials and Methods: In this experimental study, 16 wistar rats were selected as the research sample. After injection of nicotinamide and streptozocin to induce diabetes, the rats were randomly divided into two groups of resistance training and control. The resistance group participated in a course of resistance training for up to 12 week in five sessions per week, with intensity of 75% and a time of 30 to 45 minutes. Finally, 48 hours after the last exercise session, G6Pase expression in liver cells, as well as glucose and insulin levels were measured in both groups.

Results: Comparison of resistance and control training groups showed a decrease in glucose levels (P-value= 0.001) and increased insulin levels (P-value= 0.001). Exercise also reduced the expression of G6Pase in liver cells in the resistance training group (P-value= 0.001).

Conclusion: Based on the results of the study, it is recommended that diabetics use resistance training under the supervision of a specialist to reduce the negative effects of diabetes.