The Impact of Orlistat on Diabetic Patients Experiencing Overweight and Constipation: A Randomized Clinical Trial

Mohsen  Zabihi; Fatemeh  Naseri; Azam  Ghanei

doi:10.18502/ijdo.v17i3.19263

Mohsen Zabihi Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Fatemeh Naseri Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Azam Ghanei Department of Internal Medicine, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

DOI: https://doi.org/10.18502/ijdo.v17i3.19263

Keywords: Diabetes mellitus, Orlistat, Constipation, Obesity, Clinical trial

Abstract

Objective: Obesity is a global health concern, the use of Orlistat as an anti-obesity drug, has shown promise inmanaging the constipation and blood sugar levels in diabetic patients. This study aimed to evaluate the impactof Orlistat on diabetic patients experiencing both overweight and constipation.

Materials and Methods: A total of 80 overweight and constipated diabetic patients were randomly enrolled.Participants were randomly assigned to either the intervention or control group. The intervention groupreceived 120 mg Orlistat with lunch for three months, while the control group received placebo, taken oncedaily with lunch for the same duration. Clinical and paraclinical parameters, including body mass index (BMI),constipation, fasting blood sugar (FBS), HbA1C, triglycerides (TG), cholesterol (CHL), high-densitylipoprotein (HDL), creatinine (Cr), aspartate transaminase (AST), alanine transaminase (ALT), and bloodsugar two hours postprandial (BS-2HPP), were assessed before and after the intervention.

Results: Significantly, the BS-2HPP and ALT decreased in the interventiom group. Additionally, there was anoteworthy improvement in constipation within the intervention group compared to the control group.

Conclusion: Orlistat demonstrates some effectiveness in improving clinical parameters in diabetic patientswith obesity and constipation. While the drug shows notable efficacy in alleviating constipation, its impact onother related parameters is not statistically significant. No significant side effects were observed with Orlistat