Effects of Lipoic Acid and High-Intensity Interval Training (HIIT) on Pancreatic VEGFR-3 Levels in Diabetic Rat Model

Authors

  • Seyed Ramin Hashemian Esfahani Department of Physical Education, Azadshahr Branch, Islamic Azad University, Azadshahr, Iran.
  • Minoo Dadban Shahamat Department of Physical Education, Azadshahr Branch, Islamic Azad University, Azadshahr, Iran.
  • Asra Askari Department of Physical Education, Gorgan Branch, Islamic Azad University, Gorgan, Iran.
  • Abbas Nezhadebrahimi Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

DOI:

https://doi.org/10.18502/ijdo.v16i2.15709

Keywords:

ALA, HIIT, Lymph angiogenesis, Diabetic model rats

Abstract

Objective: The purpose of this experimental research is to investigate the effects of High-Intensity Interval Training (HIIT) and Lipoic Acid (ALA) supplementation on VEGFR-3 of pancreatic in diabetic Wistar rats model.

Materials and Methods: 20 male Wistar rats weighing 159 ± 3 gr and aged3 weeks, were randomly assigned into 4 groups:1) diabetes/sham, 2)diabetes/ ALA, 3)diabetes/exercise/sham, and 4) diabetes /exercise/ ALA. Diabetes was induced with streptozotocin (65 mg/kg dose) and Nicotinamide (120 mg/kg dose). After two weeks of familiarization with interval training, the rats started their main training, included 10 repetitions of 4 minutes of running on the treadmill with an intensity of 85-90% VO2max and 2 minutes of active rest between repetitions (5-10 m/min) for 5 sessions per week for 6 weeks. ALA supplement was taken at a dose of 20 mg/kg/day for 6 weeks. One-way ANOVA test used and Tukey's post hoc test at for analysis (P≤ 0.05).

Results: HIIT has a significant effect on blood glucose (P= 0.004) and insulin (P= 0.001) and VEGFR3 (P= 0.001) of pancreatic tissue of diabetic rats.

Conclusion: Lymphatic vessels play an important role in the pancreas and treat diabetes.The results of this research showed that HIIT and ALA increased lymphangiogenesis in the diabetic rat model.

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Published

2024-06-15

Issue

Volume (16) issue (2)

Section

Articles