Evaluation of Anemia Effect on HbA1c Level Measurement in Type 2 Diabetic People

Samira Kashani; Zahra Hesari; Faramarz Koohsar; Khodaberdi Kalavi; Mohammad taher Hojjati

doi:10.18502/ijdo.v16i1.15239

Samira Kashani Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Zahra Hesari Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Faramarz Koohsar Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Khodaberdi Kalavi Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Mohammad taher Hojjati Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran

DOI: https://doi.org/10.18502/ijdo.v16i1.15239

Keywords: HbA1c, Diabetes, RBC indices, Hemoglobinopathies, Anemia

Abstract

Objective: For many years HbA1c used as diagnostic criteria for diabetes, however, measurement of HbA1 has some limitations that cannot be accurately assess blood glucose levels in conditions such as changes in red blood cell life. in this study, we evaluated and compared the levels of HbA1C in diabetic, pre-diabetic and non- diabetic individuals to understand the role and relationship of different values of RBC`s indices in these conditions.

Materials and Methods: This study performed between august to December of year 2021, and the demographic information and hematologic indices of 706 individuals which referred to laboratories in Gorgan city were investigated. According to results of FBS and HbA1c, individuals categorized in three distinct healthy (H), pre-diabetic (PD), and diabetic (D) groups base on latest ADA criteria.

Results: Evaluation of HbA1c level based on the presence or absence of anemia showed that in diabetic group with anemia significantly had a lower level 8.4 (± 1.5) than people without anemia 8.6 (± 1.5) (P= 0.045). Conclusion: In this study, it was shown that changes in RBC indices in anemia can lead to inaccurate measurement of HbA1c level.