Serum Chromium is Inversely Correlated with the Carotid Intima– Media Thickness in Type 2 Diabetic Subjects

Fatima Qureshi; Haji Khan Khoharo

doi:10.18502/ijdo.v15i3.13738

Fatima Qureshi Assistant Professor, Department of Biochemistry Liaquat University of Medical and Health Sciences Jamshoro, Sindh, Pakistan.
Haji Khan Khoharo Consultant Physician Professor Faculty of Medicine and Allied Medical Sciences Isra University, Hyderabad, Sindh, Pakistan.

DOI: https://doi.org/10.18502/ijdo.v15i3.13738

Keywords: Serum chromium, Carotid intima - media thickness, Atherosclerosis, Diabetes mellitus

Abstract

Objective: The aim of this study was to determine and correlate the serum chromium in Carotid intima - media thickness (CIMT) in type 2 Diabetes Mellitus (T2DM) subjects.

Materials and Methods: The present case – control study included 40 healthy controls and 45 T2DM subjects that were selected through non-probability (purposive) sampling by prior inclusion and exclusion criteria. Serum chromium (Cr) was detected and measured on inductively coupled “Plasma Optical Emission Spectrophotometer” (ICP- OES)- Carotid artery was examined with a 7.5-MHz linear-array transducer (Siemens Acuson x300) sonography. Data was analyzed by Student’s t test and Chi square test in the SPSS 22.0 (USA). Linear regression model was used for predicting carotid intima media thickness. Level of confidence interval of statistical significance was 95% (P≤ 0.05).

Results: Serum Cr in controls and cases was noted 0.873 (± 0.162) and 0.281 (± 0.240) µg/ml (P= 0.001). Serum Cr proved negative correlation with random blood sugar (r= -0.145, P= 0.185), HbA1c (r= -0.145, P= 0.0001) and CIMT (r= -0.730, P= 0.0001). Multiple regression analysis model showed significant association of serum Cr (r= -0.730, P< 0.0001) and HbA1c (r= 0.754, P< 0.0001) with the CIMT.

Conclusion: The present study reported serum Cr was inversely correlated with the carotid intima - media thickness that is a marker of atherosclerosis. Cr supplements may be advised to diabetics in clinical management.