The Effect of Combined Exercises and Consumption of Mulberry Leaf Extract on Serum Inflammatory Markers Level in Elderly Type 2 Diabetes Mellitus Men

Mohammad Ebrahim Bahram; Roghayyeh Afroundeh; Mohammad Javad Pourvaghar; Farnaz Seify Skishahr; Leila Katebi; Ozkan Isik

doi:10.18502/ijdo.v15i3.13733

Mohammad Ebrahim Bahram Ph.D. Students in Sports Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
Roghayyeh Afroundeh Associate Professor of Sports Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
Mohammad Javad Pourvaghar Associate Professor, Department of Physical Education and Sport Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran.
Farnaz Seify Skishahr Associate Professor of Sports Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
Leila Katebi Assistant Professor, Department of Pediatrics, School of Medicine Bu'ali Hospital, Ardabil University of Medical Sciences, Ardabil, Iran.
Ozkan Isik Associate Professor, Faculty of sport Sciences, Balikesir University, Balikesir, Turkey.

DOI: https://doi.org/10.18502/ijdo.v15i3.13733

Keywords: Interleukin 6, Salusin-α, Salusin-β, Diabetes, Elderly

Abstract

Objective: This study aimed to investigate the effect of 8 weeks combined exercise and consumption of Mulberry leaf extract on the serum levels of inflammatory and atherosclerosis indicators in elderly men with type 2 diabetes mellitus (T2DM).

Materials and Methods: 40 elderly men T2DM aged between 65 to 70 years old were purposefully selected and randomly divided into five equal groups (training, supplement, training+ supplement, placebo, and control). A daily dose of 1000 mg Mulberry leaf extract, 3 times a day, was used for 2 months by the supplement group. Training groups performed combined exercises for eight weeks, each week three sessions of 90 minutes.

Results: The results showed that the amount of salusin-β and interleukin-6 in the training, training + supplement and supplement groups decreased significantly at the end of the study; Meanwhile, the level of salusin-α increased significantly in the training (P= 0.001), training + supplement (P= 0.001) and supplement (P= 0.01) groups. Also, the results of the covariance analysis showed that the amount of salusin-β and interleukin 6 were lower (P= 0.001), and the level of salusin-α was higher significantly in the training (P= 0.001), training +supplement (P= 0.001), and supplement (P= 0.001) groups compared to the control groups.

Conclusion: It seems that the consumption of Mulberry leaf extract, and combined exercises, is effective in controlling the inflammatory indicators and atherosclerosis related to diabetes in the T2DM elderly.