Effect of Concurrent Resistance-Aerobic Training on Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Pediatric Type 1  Diabetes: A Randomized Trial

Marzieh  Nazari; Ramin  Shabani; Setila  Dalili

doi:10.18502/ijdo.v15i1.12211

Marzieh Nazari Ph.D Candidate of Exercise Physiology, Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, Iran.
Ramin Shabani Department of Exercise Physiology, Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, Iran.
Setila Dalili Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.

DOI: https://doi.org/10.18502/ijdo.v15i1.12211

Keywords: Diabetes mellitus, Neutrophil- lymphocyte ratio, Platelet-lymphocyte ratio, Pediatric

Abstract

Objective: The role of post-exercise on the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) is not evident in pediatrics with type 1 diabetes (T1D) yet. This paper reports the results of a research study on how concurrent exercise training affects NLR and PLR in children with T1D.

Materials and Methods: In this randomized controlled trial, 40 children (boys and girls aged 11.11 ±2.29 years) were randomly divided into an experimental (n=20) and a control group (n=20). The training program included concurrent resistance-aerobic training, which was intermittently performed for 60 minutes at a rate of three times a week for 16 weeks. The participants were analyzed for blood glucose homeostasis, NLR and PLR before and after the program. Data were analyzed by SPSS 22 software with paired T-test and covariance analysis (P< 0.05).

Results: The results showed that PLR significantly (P= 0.002) decreased in the exercise group after 16 weeks of concurrent training. This significance was observed between the groups too (P= 0.003). HbA1c decreased both in the exercise group and between the groups (P= 0.001, P= 0.003). NLR exhibited a significant increase both in the exercise group (P= 0.021) and between the groups (P= 0.012.)

Conclusion: Concurrent exercise training reduces PLR and HbA1c in children with T1D, which may be related to the anti-inflammatory effects of exercise training.