Effect of Vitamin C Therapy on Serum Parameters in Patients with  Type 2 Diabetes Mellitus: Clinical Trial

Shiva  Kordestani; Seyyed  Behzad Razavi; Mona  Najaf Najafi; Parvin  Layegh; Mohammadmobin  Miri Moghaddam; Amirali  Aali; Masoud  Mohebbi

doi:10.18502/ijdo.v15i1.12206

Shiva Kordestani Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Seyyed Behzad Razavi Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mona Najaf Najafi Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Parvin Layegh Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammadmobin Miri Moghaddam Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Amirali Aali Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Masoud Mohebbi Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

DOI: https://doi.org/10.18502/ijdo.v15i1.12206

Keywords: Clinical trial, Diabetes mellitus, Blood glucose, HbA1C, HDL, LDL, Ascorbic acid

Abstract

Objective: Diabetes mellitus (DM) is a leading cause of morbidity and death worldwide. DM will affect 570.9 million people worldwide by 2025. The usefulness of vitamin C in improving diabetes control has been a point of contention.

Materials and Methods: This clinical-trial double-blind study with control groups was conducted on 164 patients with type 2 diabetes mellitus (T2DM). The intervention group received 1000 mg of oral vitamin C daily, and a placebo was administered to the controls. To analyze the obtained data, one-way ANOVA was used in SPSS software (version 20). A P< 0.05 was considered statistically significant.

Results: Fasting blood sugar (FBS), hemoglobin A1c (HbA1C), triglyceride (TG), and high-density lipoprotein (HDL) were improved significantly in the intervention group (P< 0.05), while the low-density lipoprotein (LDL) and cholesterol were unaffected (P> 0.05). HbA1C and LDL levels in the control group increased significantly (P< 0.05). Meanwhile, this group's HDL levels decreased considerably.

Conclusion: Our findings support the consumption of vitamin C to complement the primary treatment for DM. According to our results, vitamin C provides a clear benefit over a placebo in the treatment of diabetic patients' serum parameters.