The Effect of Oral Selenium on the Size of Thyroid Nodules in Patients with Benign Thyroid nodules: A Brief Study

Samane Moradi; Seyed Mohammad  Mohammadi; Nasim Namiranian; Mohammad Afkhami-Ardekani; Omid  Afkhami-Ardakani

doi:10.18502/ijdo.v14i4.11229

Samane Moradi Departments of Internal Medical, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Seyed Mohammad Mohammadi Endocrinology & Metabolism, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Nasim Namiranian Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammad Afkhami-Ardekani Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Omid Afkhami-Ardakani Student, Factualty of Medicine, Pecs University, Hungary.

DOI: https://doi.org/10.18502/ijdo.v14i4.11229

Keywords: Selenium, Thyroid gland, Nodule

Abstract

Objective: The thyroid gland is susceptible to the formation of nodules. Therefore, due to the critical role of selenium in the function of the thyroid gland, the impact of this element on the size and volume of this organ and its nodules were examined.

Materials and Methods: During three months, two groups consisting of 30 patients with benign thyroid nodules who were referred to Baghaeipour Endocrinology Clinic were given daily doses of 100 and 200 micrograms of selenium, and a control group of 30 people without selenium consumption were assessed.

Results: The results of intergroup analysis detected that the mean (±SD) of nodules length in the 100 µg selenium consumer group was 17.13 (±7.9) and 14.93 (±6.01) before and after intervention respectively (P= 0.008). About the nodules height in the 200 µg selenium consumer group, the mean (±SD) was 9.3 (±2.8) and 8.93 (±2.71) before and after intervention in that order (P= 0.001).

Conclusion: Our findings suggest that selenium has been effective in the size and volume of the nodule and thyroid gland, as well as the TSH hormone, and further studies are needed to determine its therapeutic approach and efficacy.