Investigation of NUDT15 Allele Frequency in a Group of Iranian Population

Authors

  • Negar Sarhangi Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  • Mandana Hasanzad Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  • Fatemeh Rouhollah Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  • Shekoufeh Nikfa Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  • Farshad Sharifi Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  • Negar Niknam Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

DOI:

https://doi.org/10.18502/ijdl.v25i2.20223

Keywords:

Personalized Medicine, Precision Medicine, Pharmacogenomics, Pharmacogenetics, Genetic Variation, Allele Frequency, Iran

Abstract

Background: Pharmacogenomics (PGx), as a growing field of personalized medicine, aims to optimize the efficacyand safety of medications by studying the association between germline genetic variations and drug responses. Thepresent cross-sectional study aims to evaluate the allele frequency of the NUDT15 genetic variant in the Iranianpopulation to provide insights into personalized treatment decisions in the Iranian population.

Methods: A representative sample set of 1142 unrelated healthy Iranian individuals aged 18 and older genotyped usingthe Infinium Global Screening Array-24 BeadChip.

Results: We identified a pharmacogenetic variant with minor allele frequency (MAF) ≥1% among the present studiedpopulation which may explain the substantial variability in drug response phenotypes among different populations

Conclusion: The results of our study revealed significant genetic variation among Iranian populations that couldsignificantly influence clinical decision-making. This study shows the frequency pattern of the effective variant ofNUDT15 in determining the phenotype in Iranian population.

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Published

2025-11-22

Issue

Volume (25) issue (2)

Section

Articles