The Effect of Resistance Training on PI3K/AKT1/M Torc 1 Signaling Axis and Cardiac Hypertrophy in Diabetic Obese Rats

Mohammad  Dastyar; Fatemeh Nikseresht

doi:10.18502/ijdl.v25i1.20212

Mohammad Dastyar Ahvaz City Education Department, Khuzestan, Iran
Fatemeh Nikseresht Department of Physical Education, Farhangian University, Tehran, Iran

DOI: https://doi.org/10.18502/ijdl.v25i1.20212

Keywords: physiological cardiac hypertrophy, Gene expression, Resistance training, Diabetes.

Abstract

Background: The aim of this study was to determine effect of resistance training on the expression of PI3K, AKT1 and mTORc1 in the heart tissue of type 2 diabetes rats and their physiological cardiac hypertrophy.

Methods: 21 male wistar rats (220±20 g) were obese by 6 weeks high fat diet (HFD). After inducing obesity, T2D induced by intraperitoneal injection of streptozotocin (30 mg/kg) in 14 rats. Finally, the rat were randomly assigned to 1) non-diabetes, 2) control T2D, 3) resistance diabetes groups. Rats in the resistance group were completed a resistance training program, 5 sessions weekly for 6 weeks. PI3K, AKT1 and mTORc1 expression and the weight ratio of left ventricular to heart, left ventricular to body and heart to body were compared by ANOVA between groups.

Results: In response to induction of diabetes, the expression of PI3K, AKT1 and mTORc1 in heart tissue decreased significantly compared to the non-diabetic group (p < 0.05). Resistance training resulted in significant increase in the expression of PI3K, AKT1 and mTORc1 and the weight ratio of left ventricular to heart, heart to body and left ventricular to body compared to control diabetes rats (p < 0.05).

Conclusion: Resistance training is associated with physiological cardiac hypertrophy in diabetic rats, and this improvement can be attributed to the PI3K/AKT1/mTORc1 signaling pathway