Study the Relation of Serum Level of IL-33 with Severity of COPD  Disease

Hossein Ali  Khazaie; Nazar Ali  Molaie; Forugh  Forughi; Arewic  Gowrkian; Javid  Dehghan; Javad  Mahmodi

doi:10.18502/igj.v6i1.16342

Hossein Ali Khazaie Clinical Immunology Research Center (CIRC), School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Nazar Ali Molaie Clinical Immunology Research Center (CIRC), School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Forugh Forughi Clinical Immunology Research Center (CIRC), School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Arewic Gowrkian Zahedan University of Medical Sciences, Zahedan, Iran
Javid Dehghan Department of community Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Javad Mahmodi Zahedan University of Medical Sciences, Zahedan, Iran

DOI: https://doi.org/10.18502/igj.v6i1.16342

Keywords: Cytokine; IL-33; Severity; Chronic Obstructive Pulmonary Disease; COPD

Abstract

Background: Cytokines are important in many pathobiological processes of chronic obstructive pulmonary
disease (COPD). This study aimed to determine the relationship between serum levels of interleukin-33 (IL33) and the severity of COPD disease.

Method: In this cross-sectional research, the study population consisted of all COPD patients referring to
the pulmonary clinic of Imam-Ali Hospital of Zahedan city in 2014. Sixty patients were selected using the
available sampling method. Serum IL-33 levels were measured by the quantitative ELISA method.

Results: Of 60 patients, 23 (38.3%) and 37 (61.7%) subjects were male and female, respectively. Analysis shows
a significant difference between serum IL-33 of the two groups with regard to the severity of COPD disease.
There was a statistically significant negative relationship between the serum level of IL-33 and the severity
(decrease of forced expiratory volume in one second (FEV1)) of COPD disease.

Conclusion: : Our results indicate a systemic release of IL-33 correlated with the severity of COPD.