Evaluating the Impact of Different Genetic Variants on the Prognosis of Patient with COVID-19

Soroush Najdaghi; Farzaneh Darbeheshti; Sepideh Razi; Mahsa Keshavarz-Fathi; Simin  Ghaemkhah; Vahid Shaygannejad

doi:10.18502/igj.v5i3.16037

Soroush Najdaghi Isfahan Neurosciences Research Center, Isfahan University of Medical Science, Isfahan, Iran
Farzaneh Darbeheshti Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Sepideh Razi Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Mahsa Keshavarz-Fathi Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Simin Ghaemkhah Isfahan Neurosciences Research Center, Isfahan University of Medical Science, Isfahan, Iran. Isfahan Neurosciences Research Center, Isfahan University of Medical Science, Isfahan, Iran.
Vahid Shaygannejad Isfahan Neurosciences Research Center, Isfahan University of Medical Science, Isfahan, Iran.

DOI: https://doi.org/10.18502/igj.v5i3.16037

Keywords: COVID-19; SARS-CoV-2; Polymorphism; Prognosis; Host Genetic Factors; Susceptibility

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 in Wuhan (China). It soon became widespread so that the World Health Organization (WHO) declared the outbreak of COVID-19 as a pandemic crisis. This disease has caused significant morbidity and mortality in the world. Clinical studies reported that there is a significant correlation between genders, immunogenetic variants, serum levels of some circulating factors, blood groups, and different races with severity and mortality of COVID-19 patients. Hence, some studies have investigated the role of individual genetic background in the susceptibility and vulnerability to COVID-19 infection. It is proposed that host genetic polymorphisms affect the onset and progression of COVID-19 infection and could dramatically impact the virus life cycle. This paper aims to review the state-of-the-art research on the roles of genetic variants in host cell membrane proteins and blood circulation factors in the prognosis of patients with COVID-19.