The Comparison of Immunohistochemistry Characteristics Between Breast Cancer Patients Under 35 Years Old and Above

Golareh Saeidpour; Marzieh Lashkari; Ramtin  Saeidpour; Ali Mir

doi:10.18502/ajs.v7i1.16348

Golareh Saeidpour General Physician, Tehran University of Medical Sciences, Tehran, Iran
Marzieh Lashkari Associate Professor, Radiation Oncology, Tehran University of Medical Sciences, Radiation Oncology Research Center, Iran Cancer Institute, Tehran, Iran
Ramtin Saeidpour Student Research Committee, Dezful University of Medical Sciences, Tehran, Iran
Ali Mir Assistant Professor of Breast Surgery, Tehran University of Medical Sciences, Surgery Department, Shariati Hospital, Tehran, Iran

DOI: https://doi.org/10.18502/ajs.v7i1.16348

Keywords: Breast Cancer, Very Young, Immunohistochemistry, Prognosis

Abstract

The increasing incidence rate of breast cancer in young women necessitates investigations of clinical and pathological features in this age group. Less hormone receptor expressions and more aggressive behavior have been discussed in very young breast cancer patients. In this study, pathological data of patients diagnosed with Invasive ductal carcinoma referred to Shariati hospital and Tehran cancer institute between 2015 and 2018 was evaluated in two groups: under 35 years old (Group 1) and above (Group 2). Each group contained 156 cases. Estrogen and Progesterone Receptor expression was reported in 62.8% and 63.5% of Group 1, in comparison to 77.6% and 74.4% in Group 2 (P value= 0.004 and 0.0038). Her2 expression was found in 41% of Group 1 and 21.2% of Group 2 (P value= 0.0001). Ki67 was reported as 41.2 ± 25.2 in Group 1 and 29.6 ± 21.7 in Group 2 (P value= 0.001). In conclusion, negative hormone receptor, positive Her2 expression, and higher proliferation rates are found in breast cancer patients under 35 years old.