Relationship Between Uric Acid/HDL Ratio, Biochemical, and Hematological Parameters in Type 2 Diabetic Patients with and Without Nephropathy

Authors

  • Mohammed Fadhil Ajeel Alshammari Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  • Fatemeh Sadat Hoseini Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  • Hossein Mokhtari Amol faculty of paramedicine, Mazandaran university of medical sciences, Sari, Iran
  • Hadis Musavi Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  • Abbas Khonakdar-Tarsi Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

DOI:

https://doi.org/10.18502/abi.v4i2.23037

Keywords:

Type 2 Diabetes Mellitus, Diabetic Nephropathy, Uric Acid-to-HDL Ratio, HbA1c, Glycemic Control

Abstract

Objectives: Diabetic nephropathy (DN) is a major complication of type 2 diabetes mellitus (T2DM). This study aims to evaluate the association of the uric acid-to-high- density lipoprotein cholesterol ratio (UHR) with biochemical parameters in patients with and without DN.

Methods: In this comparative cross-sectional study, 120 patients with T2DM (60 with DN and 60 without DN) were enrolled. Clinical, biochemical, lipid, renal, inflammatory, and hematological parameters were measured. Correlations between UHR and glycemic indices were analyzed, and receiver operating characteristic (ROC) analysis was performed.

Results: Patients with DN had higher triglyceride and creatinine levels, lower high- density lipoprotein cholesterol (HDL-C) levels, and borderline higher UHR (P=0.05) than those without DN. No significant differences were found for HbA1c, fasting blood glucose, postprandial glucose, mean plasma glucose, triglyceride-glucose index, or serum uric acid. UHR was not significantly correlated with any glycemic index (all P>0.05). ROC analysis showed poor discriminatory performance of UHR for DN (AUC=0.452, P=0.475).

Conclusion: Although UHR was borderline elevated in patients with DN, it was not associated with glycemic indices and showed poor diagnostic performance. These findings suggest that UHR has limited utility as an independent biomarker of diabetic nephropathy in T2DM.

Published

2026-10-25

Issue

Volume (4) issue (2)

Section

Articles