Effects of the combination of Curcumin Supplementation and Aerobic Exercise on Lipid Profile and Oxidative Stress in Type 2 Diabetic Wistar Rats

Atosa  Gorji; Javad  Ramezani; Farid  Mahinizadeh; Pooya  Javaherchian; Matin  Mohyadini

doi:10.18502/abi.v3i4.21849

Atosa Gorji Department of Exercise Physiology and Sport Sciences, Islamic Azad University, Yazd Branch, Yazd, Iran
Javad Ramezani Department of Sports Sciences, Payame Noor University (PNU), Tehran, Iran
Farid Mahinizadeh Department of Clinical Biochemistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Pooya Javaherchian Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Matin Mohyadini Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

DOI: https://doi.org/10.18502/abi.v3i4.21849

Keywords: Aerobic exercise, Curcumin, Diabetes mellitus, Lipid profile, Oxidative stres

Abstract

Objectives: Dyslipidemia and oxidative stress have been reported to play importantroles in the pathogenesis of type 2 diabetes mellitus (T2DM) complications. This studyaimed to test the hypothesis whether curcumin supplementation combined with aerobicexercise could prevent dyslipidemia and oxidative stress in a rat model of T2DM.

Methods: Male Wistar rats with nicotinamide-streptozotocin-induced T2DM weredivided into four groups including untreated diabetes, diabetes treated with curcumin (30mg/kg, three times weekly), diabetes treated with aerobic exercise (4-week progressivetreadmill training), and a combination group. Also, healthy control groups (untreated,curcumin-treated, and curcumin + aerobic-treated) were studied to determine the sideeffects of the treatments. Fasting blood sugar (FBS), lipid profiles (triglycerides, totalcholesterol, LDL, HDL) and antioxidant enzyme activities (catalase, SOD, GPx) weremeasured by commercial kits after 4 weeks of treatment protocol.

Results: Diabetic rats had significantly elevated serum levels of FBS, triglycerides, totalcholesterol, LDL, and reduced antioxidant activities compared to controls. Curcumin andaerobic exercise alone improved these parameters significantly, but their combinationwas more effective in reducing FBS, improving lipid profiles, and boosting antioxidantactivities.

Conclusion: The combination of curcumin and aerobic exercise has more potential toameliorate dyslipidemia and oxidative stress in T2DM rats, compared to treatmentsindividually. These findings require further exploration in clinical settings