Serum CTRP1 Levels in Candidates for Coronary Artery Bypass Graft

Hossein  Pourghadamyari; Zohreh  Ramazani-Karim; Mohammad  Hajializadeh; Esmaeil Sajadi  Moghadam; Hossein  Borji; Hadis  Ahmadirad; Asie  Sadeghi

doi:10.18502/abi.v3i2.19489

Hossein Pourghadamyari Applied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran
Zohreh Ramazani-Karim Department of Clinical Biochemistry, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Mohammad Hajializadeh Medical Student, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Esmaeil Sajadi Moghadam Department of Nursing, School of Nursing and Midwifery, Bam University of Medical Sciences, Bam, Iran
Hossein Borji Shafa Hospital, Department of Cardiac Surgery, Kerman University of Medical Sciences, Kerman, Iran
Hadis Ahmadirad Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Asie Sadeghi Department of Clinical Biochemistry, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran

DOI: https://doi.org/10.18502/abi.v3i2.19489

Keywords: Type 2 Diabetes (T2D), Resistance Training (RT), Aerobic Training (AT), Blood Flow Restriction (BFR)

Abstract

Objectives: C1q/tumor necrosis factor-related protein 1 (CTRP1) is an adipokine that plays crucial roles in the cardiovascular system, and its dysregulation has been reported in patients with coronary artery disease (CAD). In this study, our aim was to measure the level of CTRP1 in patients who were candidates for cardiac bypass surgery.

Methods: The participants consisted of 30 candidates for coronary artery bypass graft (CABG) surgery and an additional 30 controls. Inflammatory parameters and the level of CTRP1 were assessed using enzyme-linked immunosorbent assay (ELISA) kits.

Results: Serum CTRP1 levels significantly increased in the patient group compared to the control group (p-value < 0.0001). Furthermore, CTRP1 level was positively correlated with the inflammatory parameters.

Conclusion: Elevated levels of CTRP1, along with inflammation in CAD, suggest the involvement of CTRP1 in inflammatory responses. However, this finding needs to be confirmed in further studies including a larger population