Beta Boswellic Acid Reduces Tau Phosphorylation Level and Enhances Reelin Expression in the brain

Marzieh Dehghan  Shasaltaneh; Sadrollah  Ramezani; Nasser  Naghdi; Gholam Hossein  Riazi

doi:10.18502/abi.v3i1.19350

Marzieh Dehghan Shasaltaneh Department of Biology, Faculty of Science, University of Zanjan, Zanjan, Iran.
Sadrollah Ramezani University of Sistan and Baluchestan, Zahedan, Iran.
Nasser Naghdi Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran.
Gholam Hossein Riazi Laboratory of Neuro-organic Chemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran

DOI: https://doi.org/10.18502/abi.v3i1.19350

Keywords: Boswellic Acid, Histological Analysis, Reellin, Memory Consolidation, Learning

Abstract

Objectives: Learning and memory retention involve a permanent change in behavior based on environmental adaptation. Reelin protein plays a role in learning and memory but has not been extensively studied in the presence of herbal components. This study examines the effect of an optimum dose of beta-boswellic acid (BBA) on reducing tau phosphorylation levels and enhancing Reelin expression in the hippocampus to improve cognitive behavioral outcomes..

Methods: Spatial memory, learning, and locomotor activity were assessed. Histological and Western blot analyses were performed.

Results: The findings demonstrate a significant effect of BBA (35 μg/kg body weight) on memory consolidation during the probe trial of the Morris Water Maze (MWM) test. BBA treatment reduced the formation of dark neurons in the hippocampus and promoted Reelin expression.

Conclusion: A specific dose of BBA enhanced memory consolidation in adult rats, with increased Reelin protein expression—likely due to BBA’s anti-inflammatory properties, a key factor contributing to improved memory performance.