Effectiveness of hydroalcoholic extract of Nasturtium Officinale on sleep quality, asthma control and quality of life in asthmatic patients: a randomized controlled trial

Reza Abbasi; Ezzat Zarei; Nasrin Shakerinasab; Mahdieh Eftekhari; Hossein Sadeghi; Ali Fazel; Amir-Hossein Doustimotlagh; Fatemeh Bazarganipour

doi:10.18502/abi.v2i1.16247

Reza Abbasi Medicinal plants Research Center, Yasuj University of Medical Sciences, Yasuj Iran
Ezzat Zarei Medicinal plants Research Center, Yasuj University of Medical Sciences, Yasuj Iran
Nasrin Shakerinasab Medicinal plants Research Center, Yasuj University of Medical Sciences, Yasuj Iran
Mahdieh Eftekhari Medicinal plants Research Center, Yasuj University of Medical Sciences, Yasuj Iran
Hossein Sadeghi Medicinal plants Research Center, Yasuj University of Medical Sciences, Yasuj Iran
Ali Fazel Medicinal plants Research Center, Yasuj University of Medical Sciences, Yasuj Iran
Amir-Hossein Doustimotlagh Medicinal plants Research Center, Yasuj University of Medical Sciences, Yasuj Iran
Fatemeh Bazarganipour Medicinal plants Research Center, Yasuj University of Medical Sciences, Yasuj Iran

DOI: https://doi.org/10.18502/abi.v2i1.16247

Keywords: asthma, quality of sleep, asthma control, quality of life, Nasturtium officinale

Abstract

Objectives: Considering the role of oxidants in asthma, airway inflammation, and the anti-inflammatory effects of Nasturtium officinale extract, this study aimed to investigate the impact of the hydroalcoholic extract of Nasturtium officinale on sleep quality, asthma control, and quality of life in asthmatic patients.

Methods: This parallel group randomized clinical trial was conducted in Yasuj, Iran. It included 60 patients who randomly received either Nasturtium officinale hydroalcoholic extract (500 mg daily, for four weeks, orally plus routine care) or a placebo (500 mg capsule containing flour daily, for four weeks, orally plus routine care). To achieve the study objectives, lung function (FEV1, FVC, PEF, FEF 25-75%, and FEV1/FVC), quality of life as measured by the 12-item Short Form Health Survey (SF-12), sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI), and asthma control as examined by the Asthma Control Test (ACT) were assessed at baseline and one-month follow-up.

Results: In total, 48 patients (22 patients in the intervention group and 26 patients in the control group) completed the study. The analyses showed no significant differences between the two groups regarding changes in lung function, quality of life, sleep quality, and status of asthma control within a one-month follow-up.

Conclusion: The findings suggest that the hydroalcoholic extract of Nasturtium Officinale does not appear to improve sleep quality, asthma control, and quality of life in asthmatic patients in the short term.