Inflammatory indices IL-6, TNF-α, CRP, and hs-CRP in candidates for coronary artery bypass graft surgery

Hossein Pourghadamyari; Esmaeil sajadi moghadam; Mohsen Eghbali; Hossein Borji; Masood Dialamy; Asie Sadeghi

doi:10.18502/abi.v1i3.14548

Hossein Pourghadamyari Applied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran
Esmaeil sajadi moghadam Department of Nursing, school of Nursing and midwifery, Bam University of Medical Sciences, Bam Iran
Mohsen Eghbali Medical Student, School of Medicine, Kerman University of Medical Sciences
Hossein Borji Shafa Hospital, Department of cardiac surgery, Kerman University of Medical Sciences
Masood Dialamy Shafa Hospital, Department of cardiac surgery, Kerman University of Medical Sciences
Asie Sadeghi Applied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran

DOI: https://doi.org/10.18502/abi.v1i3.14548

Keywords: Coronary Artery Bypass Graft; CRP; hs-CRP; IL-6; TNF-α

Abstract

Objectives: The elevation of inflammatory factors, such as tumor necrosis factor α (TNF-α) and high-sensitivity C-reactive protein (hs-CRP), is associated with a high risk of coronary artery disease (CAD). The primary objective of the present study was to identify the primary inflammatory factors in patients who were candidates for coronary artery bypass graft (CABG).

Methods: This study included 30 subjects scheduled to undergo CABG surgery, as well as 30 control subjects. Serum levels of hs-CRP, interleukin 6 (IL-6), and TNF-α were analyzed using enzyme-linked immunosorbent assay (ELISA) kits.

Results: There were no significant differences in body mass index (BMI) and age between the patient and control groups. However, the patient group had significantly higher triglyceride (TG) levels compared to the control group (P < 0.05). Additionally, the patient group exhibited significantly elevated levels of inflammatory cytokines IL-6 and TNF-α (P < 0.001 for both), as well as higher circulating levels of CRP and hs-CRP compared to the control group.

Conclusion: The findings of the present study indicated that patients recommended for surgical intervention often have elevated levels of inflammatory factors. It is advisable to take these findings into consideration before proceeding with surgery.