The emerging role of MALAT1 lncRNA in diabetic nephropathy: based on the review of the literature and bioinformatic analysis

Shekoofeh Nikooei; Erfan Azadifar; Behnam Alipoor

doi:10.18502/abi.v1i3.14545

Shekoofeh Nikooei Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran.
Erfan Azadifar Department of Laboratory Sciences, Faculty of Paramedicine, Yasuj University of Medical Sciences, Yasuj, Iran.
Behnam Alipoor Department of Laboratory Sciences, Faculty of Paramedicine, Yasuj University of Medical Sciences, Yasuj, Iran.

DOI: https://doi.org/10.18502/abi.v1i3.14545

Keywords: long Noncoding RNA, MALAT1, MicroRNA, Diabetic Nephropathy

Abstract

Previous studies have found that the metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) exerts its biological effects on the progression of diabetic nephropathy by sponging microRNAs and affecting the gene transcription of downstream molecules. In this study, the primary emphasis is placed on the functions that MALAT1 plays in relation to the pathophysiology of diabetic nephropathy as well as the processes that underlie these roles. In addition, the usage of this long noncoding RNA as a possible biomarker or therapeutic target for diabetic nephropathy will be discussed.