The relationship between chemerin gene polymorphism and the incidence of various diseases

Sahar Mazloomi; Mohammad Taghi Goodarzi

doi:10.18502/abi.v1i2.14102

Sahar Mazloomi Department of Clinical Biochemistry, Medical School. Hamadan University of Medical Sciences, Hamadan, Iran
Mohammad Taghi Goodarzi Department of Biochemistry, Shahrood Branch, Islamic Azad University, Shahrood, Iran

DOI: https://doi.org/10.18502/abi.v1i2.14102

Keywords: Chemerin, gene polymorphism, diabetes, adipokines

Abstract

Adipose tissue is recognized as an endocrine organ that influences the health status of other tissues by releasing various adipokines. Chemerin is one such adipokine, and its serum level exhibits a positive correlation with the amount of fat tissue and obesity. Certain genetic polymorphisms of chemerin, namely rs17173608, rs1799983, rs693, rs4721, and rs3735167, are known to be associated with diseases such as diabetes, gestational diabetes mellitus (GDM), obesity, insulin resistance (IR), cardiovascular diseases, metabolic syndrome (MetS), end stage renal disease (ESRD), polycystic ovary syndrome (PCOS), and rheumatoid arthritis (RA). Existing data suggest that chemerin is also associated with inflammatory diseases. This review focuses on the association between the genetic variants or polymorphisms of chemerin and some pathological states.