A Man Who Takes 26 Warfarin Pills a Day! A Case Study on Warfarin Resistance

Authors

  • Hossein Karballaei Mirzahosseini Department of Clinical Pharmacy, School of Pharmacy Semnan University of Medical Science, Semnan, Iran.
  • Leili Manafi Department of Clinical Pharmacy, Kosar Hospital, Semnan, Semnan University of Medical Sciences, Semnan, Iran.

DOI:

https://doi.org/10.18502/aacc.v12i4.21805

Keywords:

Warfarin resistance; Polymorphism; Vitamin K antagonists

Abstract

In certain patients, particularly those receiving mechanical aortic valve replacement, warfarin is the sole permitted anticoagulant. Some individuals exhibit resistance to warfarin for a variety of reasons, necessitating extremely high and occasionally fatal doses of the medication for their survival. This report details a patient who demonstrates warfarin resistance and investigates the fundamental causes of this phenomenon. The case report emphasizes the possible role of genetic polymorphism in elucidating the mechanisms behind warfarin resistance.

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Published

2026-06-21

Issue

Volume (12) issue (4)

Section

Articles