The Eftect of Paracetamol (Acetaminophen) for Postoperative Pain Control Breast Surgery: Systematic Review and Mata-Analiz Study

Mahfuz  Ghaderi; Mohammad  Esmaiel Akbari; Atieh  Akbari; Sadegh  Khoddam; Bashirjamail  Wahidi

doi:10.18502/aacc.v11i2.17967

Mahfuz Ghaderi Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Esmaiel Akbari Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Atieh Akbari Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sadegh Khoddam Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Bashirjamail Wahidi Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

DOI: https://doi.org/10.18502/aacc.v11i2.17967

Keywords: Breast surgery; Paracetamol; Acetaminophen; Systematic review; Mata analiz study

Abstract

Background: Breast surgery (BS) is one of the types of surgery that will leave complications for patients. This systematic review study was conducted with the aim of determining the effect of Paracetamol (acetaminophen) on pain after BCS using a systematic review method.

Methods: This study aimed to determine the effect of Paracetamol (acetaminophen) on pain after BCS by systematic review method and using PARISMA checklist. the search was conducted in all articles published in Scopus, ISI, PubMed, EBSCO, Embase and Google scholar search engine in the period of 1.1.2000 to 6.1.2024. The checklist included the type of surgery performed, the year the article was published, the type of pain assessment tool, the drug intervention performed, and the results of the drug’s effect on the pain of BS patients. Data analysis was done descriptively with the help of Endnote software.

Results: According to the findings in the initial search, a number of 545 articles were extracted, and according to the performed screenings, finally, 9 articles were included in the systematic review stage. In relation to pain measurement tool, VAS tool was used in 7 articles. But in the article of De Oliveira et al and colleagues, the QOR-40 scale was used, and in the article of Ohnesorge et al and colleagues, the NRS tool was used. The articles were published between 2005 and 2024. In all the articles, at least two groups were used. The findings of all studies have shown the effect of Paracetamol (acetaminophen) on pain reduction in patients after BS.

Conclusions: Considering the effect of Paracetamol (acetaminophen) on reducing the pain of patients with BS, it is suggested that this drug be prescribed to reduce the pain of these patients.