Clinical Findings and Related Factors with the Final Outcome in Hospitalized COVID-19 Patients: An Evidence Based Cross-sectional Study

Samad EJ  Golzari; Nasim Hajipoor  Kashgsaray; Ehsan  Sarbazi; Zahra  Taghavi; Saber  Ghaffari Fam; Alireza  Ala; Ali  Ostadi; Robab Mehdizadeh  Esfanjani; Sonia  Sedghian; Hassan  Soleimanpour

doi:10.18502/aacc.v11i2.17952

Samad EJ Golzari Department of Anaesthesiology and Intensive Care Medicine, Klinikum Dortmund, University Witten/Herdecke, Herdecke, Germany.
Nasim Hajipoor Kashgsaray Emergency and Trauma Care Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Ehsan Sarbazi Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Zahra Taghavi Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Saber Ghaffari Fam Department of Epidemiology, Hamadan University of Medical Sciences, Hamadan, Iran.
Alireza Ala Emergency and Trauma Care Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Ali Ostadi Department of Internal Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Robab Mehdizadeh Esfanjani Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Sonia Sedghian Department of Radiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Hassan Soleimanpour Emergency and Trauma Care Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

DOI: https://doi.org/10.18502/aacc.v11i2.17952

Keywords: COVID-19; Blood group type; Mortality; Evidence based medicine

Abstract

Background: Numerous conventional laboratory diagnostic tests has been developed to diagnose COVID-19 infection. These include but are not limited to measurement of the antibody titer against the viruses, screening the viral antigen and RT-PCR from samples obtained from nasopharynx swaps, sputum, the secretions of the lower respiratory tract, blood, and feces. Infection with SARS-CoV-2 could manifest as nonspecific symptoms such as fatigue, muscle sore, fever, and nonproductive coughs. Recent studies suggest that blood group type might play a role in determining prognosis in COVID-19 patients. Opting for the suitable diagnostic tests is essential in the timely management of these patients. In our study, we aimed at the comparison of distribution patterns of COVID 2019 and estimation of the partial frequency of the clinical findings of COVID 2019 in order to facilitate decision making of the physicians and differentiating the factors having impact on the final outcome of the hospitalized patients

Methods: In a cross-sectional descriptive-analytic study, a total of 350 patients diagnosed with COVID-19 were enrolled. The information on the previous encounters, clinical signs on admission and at the hospitalizations time, and lab results on admission were collected. Radiological findings such as chest X-ray were also collected. The questionnaires were filled out by experienced staff.

Results: A total of 350 patients with the median age of 64 years old, 204 (58.3%) male and 146 (41.7%) female were studied. 110 people (31.4%) were hospitalized in ICU. The most common underlying diseases were hypertension, diabetes, cardiac diseases, renal diseases, and cancer. Blood group types A+ and O+ were the most common blood group types among the ICU hospitalized patients P <0.0001. There was a statistically significant correlation between blood group type and mortality among the studies patients. The highest rate of the mortality was amongst patients with blood group type A+ and O+ P <0.0001.

Conclusion: Fever, fatigue and non-productive coughs, dyspnea, leukopenia, leukocytosis, lymphopenia, thrombocytopenia, thrombocytosis, increased ESR, increased CRP, and increased D-dimer are the most common clinical and laboratory findings in COVID-19 patients. A statistically significant correlation was observed between the patients hospitalized in ICU and the blood group type; the most frequent blood group type was A+ followed by O+.