Investigating the Role of Dexmedetomidine and Propofol on Fertility Rate in IVF Candidate Patients

Faranak Behnaz; Atiyeh Tizghadam; Gholamreza Mohseni; Leila Nazari

doi:10.18502/aacc.v10i3.15690

Faranak Behnaz Department of Anesthesiology, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Atiyeh Tizghadam Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gholamreza Mohseni Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Leila Nazari Department of Obstetrics and Gynecology, Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

DOI: https://doi.org/10.18502/aacc.v10i3.15690

Keywords: Propofol; Dexmedetomidine; Fertility rate; IVF

Abstract

Background: One of the most important treatments used in women with infertility is IVF, and improving its results can affect the success of assisted reproductive techniques. It was previously shown that anesthetics can enter the follicular fluid (FF), so there is concern about the accumulation of anesthetics in the FF and their negative effects on fertilization and fetal growth under general anesthesia. The use of drugs that have both analgesic and sedative effects but do not have hemodynamic side effects is of particular importance and dexmedetomidine is one of the drugs introduced in this field. On the other hand, the use of sedatives such as midazolam and propofol may cause hemodynamic disturbances and severe hypotension in these patients, which limits the use of such drugs. Accordingly, and considering the importance of the issue, in this study, we decided to evaluate and compare the effect of propofol and dexmedetomidine on fertility in IVF candidates.

Methods: In this clinical trial study, 78 infertile patients who underwent IVF were randomly examined. After dividing the patients into two groups receiving dexmedetomidine and propofol or standard recording doses, the fertility rate of the patients in the two groups was evaluated using chi-square and Fisher tests at a significance level of 0.05.

Results: The use of dexmedetomidine for (P = 0.0348) Pressure_After_Dia, HR_Before (P = 0.0204), Injection_Time (P =0.000) and Recovery Time (P =0.000) indices caused a significant increase compared to the propofol group.

Conclusion: The results of the present study did not show a significant difference in the use of these two drugs on fertility.