Inherited Unconjugated Hyperbilirubinemias and Radical Cancer surgery: Perioperative Concerns for Bilateral Modified Radical Mastectomy

Amit Kumar; Uma Hariharan; Vijay K Nagpal; Devang Bharti

doi:10.18502/aacc.v8i4.10185

Amit Kumar Department of Anaesthesiology, Atal Bihari Vajpayee Institute of Medical Sciences & Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Uma Hariharan Department of Anaesthesiology, Atal Bihari Vajpayee Institute of Medical Sciences & Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Vijay K Nagpal Department of Anaesthesiology, Atal Bihari Vajpayee Institute of Medical Sciences & Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Devang Bharti Department of Anaesthesiology, Atal Bihari Vajpayee Institute of Medical Sciences & Dr. Ram Manohar Lohia Hospital, New Delhi, India.

DOI: https://doi.org/10.18502/aacc.v8i4.10185

Keywords: Hyperbilirubinemia; Gilbert syndrome; Crigler Najjar syndrome; Glucoronosyltransferase; Anesthesia

Abstract

Inherited defects of Uridine 5'-diphospho-glucuronosyltransferase (UDPGT) can cause congenital unconjugated hyperbilirubinemia. The perioperative anesthetic management of such patients poses several challenges. Here we report a case of bilateral carcinoma breast with congenital unconjugated hyperbilirubinemia posted for bilateral modified radical mastectomy. The patient was administered general anesthesia with no perioperative deterioration of liver function.